Atkinson rose to fame playing Lisa Hunter on the Channel 4 teenage soap opera Hollyoaks. Atkinson and Marcus Patric (who played the character Ben Davies) subsequently appeared in a "spin-off" series called Hollyoaks: Let Loose for E4, in which their characters started a new life together in Chester. This was followed by Hollyoaks: In the City, also screened on E4.
Atkinson made her debut video game appearance in Command & Conquer: Red Alert 3 (2008) in the role of Lt. Eva McKenna,[6] which she reprised in Command & Conquer Red Alert 3: Uprising (2009). She also took part in EA's "Be The One" event in Trafalgar Square on 29 October 2008, which forms part of the London Games Festival.[7]
Atkinson has also played Goldie Lookin Chain's love interest in the music video for the single "R'n'B" and featured on the cover of the CD single release.[8]
In theatre, Atkinson appeared in Peter Pan at the Manchester Opera House in December 2008. She took the title role alongside John Thomson who played Captain Hook.[9]
Other TV roles included appearing as herself in the pilot for Plus One, part of the pilot series Comedy Showcase in October 2009. In early April 2009 she finished filming for an episode of The Bill. She plays Ria Crossley the girlfriend of a drug dealer.
In film, Atkinson has appeared in the British independent film Boogie Woogie,[10] which premiered at the Edinburgh International Film Festival in June 2009.[11] She has done filming for a forthcoming horror film called 13Hrs[12] in February 2009 and a new UK gangster film called Baseline[13] in March 2009.
Atkinson appeared in the West End production of Tim Firth's Calendar Girls at the Noel Coward Theatre, from July 28 to October 17 where she played the character of Elaine.[14]
Atkinson also went on tour with Calendar Girls, she played Celia aka Miss September in the production. The January to April 2010 tour of Calendar Girls also starred Lynda Bellingham, Judith Barker, Debbie Chazen, Letitia Dean and Jan Harvey.
Atkinson played the lead female role, Belinda, in Neil LaBute's play This Is How It Goes at The King's Head Theatre in Islington, London from Sept 7th - Oct 3rd 2010.
In 2010 she appeared in the film The Sweet Shop, a romantic comedy about a Hollywood superstar and a small town sweetshop owner.[15]
She finished filming in Dec 2010 on the romantic comedy How to Stop Being a Loser with Richard E. Grant, Jill Halfpenny and Pamela Anderson produced by 'Press On Features Ltd'.The film is due out in October 2011.[16]
At the beginning of May 2011 Atkinson started filming for her part in BBC 1's Casualty medical programme. She plays the part of Tamzin, a paramedic. Atkinson will appear on screen from Sat 13 August 2011. She confirmed on twitter that she was only there for 10 weeks (10 episodes)[17]
The premiere of Atkinson's latest film How to Stop Being a Loser took place on 14th Nov 2011.[18]
Her upcoming film Airborne is still in post-production. A first version has been displayed at the The Cannes Film Festival 2011.[19]
Atkinson started filming her next project on 2 Dec 2011. It is a remake of Night of the Living Dead, which is to be shot in a 3-D format. She plays Barbara, the main female character.